“21 Questions,” released on April 29, 2003, is the second single from the album. It became 50’s second number one song in the United States after “In Da Club.”

The music video for 21 Questions features cameos by G-Unit members, Lloyd Banks and Young Buck.

Lloyd Banks (left) Young Buck (right)

Kanye references “21 Questions” in “We Don’t Care”:

You know the kids gon' act a fool
When you stop the programs for after school
And they DCFS, some of ‘em dyslexic
They favorite 50 Cent song 12 Questions