This song is about how critics easily criticize artists' music and how bad it feels for the artists to take all that criticism.

Here’s an interview where he, amongst other things, discusses this very song “Fragile”
http://www.youtube.com/watch?v=h-BeXNv1xv4

Yelawolf was also to be featured on this song but his verse wasn’t sent in time (source: Something Else DVD).