The title of “A Nigga Witta Gun” is pretty self-explanatory. During the making of The Chronic, Dr. Dre drew some inspiration from the jazzy sounds of A Tribe Called Quest’s 1991 sophomore album The Low End Theory, which can be found on this track as he samples jazz musician Johnny Hammond Smith’s “Big Sur Suite” along with a sample of the drums from Whodini’s “Friends” and vocals from The Kay-Gees' “Who’s the Man? (With the Master Plan)” for the chorus.