The title track to G Rap’s first solo studio album. Like the earlier legendary songs, he doesn’t miss a spot while telling stories and describing situations. This is the first time anybody made a rap song about shooting dice.

Kool G Rap:

• “The song and album was based on a New York dice game called cee-lo. 4, 5, 6, was the equivalent to the Ace of Spades and Jack of Spades in Blackjack; it was an automatic winner. Then you could win with trips, a head crack [two dice of the same number and a third dice of six], and a few other ways. It’s just like if somebody titled something ‘Royal Flush.’ Nothing’s beating that.
  ”[After] Live And Let Die, I wasn’t with DJ Polo anymore, so I stopped using his name. I was using Roc Raida at first, and then years later I would start using different DJs."

“Plus, back then I wasn’t making an album every year. Music was lasting longer back then anyways. Today, you put an album out and it’s already old in two or three months. Back then you put out an album and dudes were rocking it that whole summer, that winter, and then the next summer.”

Source

He also said that the album took awhile because his label was going through a transitional period. 4, 5, 6 is the last album Cold Chillin' Records ever released.