In January of 2016, twenty one pilots' frontman Tyler Joseph posted a 13 second long clip of a cover of “Cancer” by My Chemical Romance. Since then, Rock Sound magazine announced the release of a The Black Parade cover album featuring a variety of different artists.

On September 13th, 2016, the twenty one pilots account released the cover via a tweet linked to a Youtube Video.

The single artwork depicts Tyler Joseph falling in a red light. The letters and colors are similar to those used on Twenty One Pilots' Blurryface, hinting at continuity of some kind. During the video, many of the books shown on the bookcases have covers similar to the patterns of the nine dots on the Blurryface album cover.

In the original MCR version of the song, the protagonist of the Black Parade album, known as “The Patient,” dies as a result of cancer.

While this is a cover of MCR, twenty one pilots definitely made it their own. While the original version relies on a driving piano and heavy vocals, the cover is more of a down-tempo electronic track. These changes give the song more of a relaxed and resigned feeling to it. The instrumentation and vocals feel subdued as if it were created by someone who has very little energy left to give.