The lyrics to the Southern Fried Intro by Ludacris are a call to action to stand up and be counted, to bring people together and to celebrate the diversity of hip hop, R&B, pop, and rock. The song expresses Ludacris' pride in his work, his creativity, and the love he has for his fans. The lyrics also talk about the struggle in life, from the hustle on the streets to the striving for fame and success.

The song speaks to a wider audience but has a particular focus on southern culture in the United States, as evidenced by the line “dirty south.” Ludacris is known for his southern rap style, which is evident in this song. The lyrics also discuss the rap scene and the difficulty of staying on top, as well as the importance of staying true to oneself and not giving in to peer pressure or external demands.