The song title references Lamar Avenue in Memphis, Tennessee. Lamar Avenue is considered to be one of the shadiest and most dangerous streets in Memphis. Most local residents and businesses will advise you to stay away from it because of its high crime rate.

The song is about the types of crimes that $lick $loth and Ruby Da Cherry are usually involved with, including drug usage, murder, and suicide. However, judging by the song title and the intro, these crimes appear to be committed specifically in Memphis, TN.