“Graduation (Friends Forever)”) is Vitamin C’s most popular hit to date. The opening lyrics to the song allude to “All the Young Dudes” by Mott the Hoople. The song also contains samples from Pachelbel’s “Canon in D” and Wolfgang Amadeus Mozart’s “Sonata for Piano and Violin in F, K. 30: 1. Adagio”.

The single reached number twelve on the Top 40 Mainstream, number twenty-three on the Rhythmic Top 40) and number thirty-eight on the Billboard Hot 100 on May 30, 2000, after reaching the Top 40 on May 9, becoming her second single to reach the Top 40. “Graduation (Friends Forever)” reached number two on the Australian ARIA Charts, peaked at number twenty-one in New Zealand on the RIANZ Charts, reached number thirteen in the Swedish Singles Chart and number four on the Irish Singles Chart. The single was certified Platinum in Australia.

The song was featured during the prom scene in the 2012 film, ‘21 Jump Street’). The song was also featured during the car scene in the movie, ‘Scary Movie’. In the scene, the main character Cindy is driving to Hell House while the song is playing the radio. She starts singing along (albeit horribly off-key) until midway through she is interrupted by Vitamin C herself who tells her to shut up and let her sing before the song resumes.

The music video for “Graduation (Friends Forever)” was directed by Gregory Dark and was filmed at Van Nuys High School.