“Medicine For Melancholy” was a surprise release solo single from Weezer frontman Rivers Cuomo.

The song is Cuomo’s first solo release since his 2011 compilation album Alone III: The Pinkerton Years.

The song deals with a relationship that provides a remedy to Cuomo’s sadness.

The title is a reference to the Ray Bradbury collection and short story of the same name. The cover image is a also a reference to a famous photograph of the author himself.