“Medicine Square Garden” is the fourth single from Frank Iero and the Future Violents' 2019 album Barriers, and Frank has said it’s the record’s “most important track”. The music video for the song premiered on April 20, 2020 and features members of GWAR attacking the band as they play during a surreal ‘80s-horror-fueled workout session.

The title could be a reference to Iero’s experience during his time with My Chemical Romance, when the band’s fame led to a performance at the renowned Madison Square Garden, whilst Iero was coping with the stresses of being in a high-profile band and constant touring by using anti-anxiety medication.