In an April 2010 interview with MTV News, Drake explained what “Miss Me” is about:

It’s a song about being away from what you love and hoping that when you’re gone, doing you, somebody out there misses you. It goes for Wayne in his situation and it goes for me in my situation, ‘cause I’m on the road for I don’t how long right now.

The song was released as the third single from Drake’s debut album, Thank Me Later. The song was originally by rapper Bun B but it had a different chorus and was entitled “All Night Long.” It was never released—instead, Drake was given the song.