Kendrick Lamar demonstrates a robust knowledge of drug culture and neurotransmitters on “A.D.H.D.” He mentions such topics as tolerance, endorphins, and cold water extraction. This knowledge does not come without some regret, as the song is largely a commentary on the prevalence of drug abuse in his generation.

The song itself utilizes a sample of “Knighthawk” from The Jet Age Of Tomorrow’s first album Voyager. The song also appeared on “Radio Los Santos” in the 2013 soundtrack for Grand Theft Auto V.