“Stuck with U” is a collaboration inspired by the global lockdown due to the 2020 Coronavirus (COVID-19) outbreak. All sales and streams from this song will proceed to First Responders Children’s Foundation, which supports grants and scholarships for children of the front lines and essential workers during the global pandemic.

Rumors of the collaboration arose when Scooter Braun, Ariana and Justin’s manager, shared a tweet with both artists' name tagged on May 1, 2020. Bieber shared the instrumental on Instagram later that day and asked fans to participate and tweet prom videos. On May 2, 2020, Grande officially announced the collaboration on Twitter.