In June 1990, “Do Me!” entered the U.S. Billboard Hot 100 singles chart at number 92. In September, the song reached number three, tying previous single “Poison” as Bell Biv DeVoe’s biggest hit on the pop charts. The song remained on the Hot 100 for 22 weeks. Elsewhere, the single peaked at number 4 on the Hot R&B/Hip-Hop Songs chart and number 6 on the Hot Dance Club Songs chart.The song ranked number 11 on the Billboard Year-End chart for 1990.