“Lay Wit Ya” is the lead single released from Isaiah Rashad’s highly-anticipated second studio album, The House Is Burning. The track features both Tennessee natives rapping over a Dirty South-inspired beat that samples a regional hit from Three 6 Mafia, “Ridin' n' tha Chevy.”

Isaiah first teased this track on April 1, 2020 in an Instagram Live session, also revealing that Hollywood Cole had produced the track. Ten months later, Isaiah and Duke Deuce were shown filming a music video to the song by TDE’s label boss Anthony “Top Dawg” Tiffith on February 1, 2021. On April 28, 2021, TDE posted a cryptic announcement revealing that something from the label was going to be coming on May 7, 2021. The release was confirmed to be “Lay Wit Ya” when the label posted a YouTube premiere that featured a copyright claim for the track in its description.