“Me & U” is a song by Cassie from her self-titled debut studio album. It was her first official music release and initially made available for streaming through her MySpace page in 2005, where it soon went viral and became a club hit in Germany.

It went on to peak in the top ten of several countries, including number three on the Billboard Hot 100 chart and spent seven weeks atop the US Airplay chart. “Me & U” has been heavily sampled and remixed by an endless list of artists and producers.