“Amoeba” is perhaps the most groovy track from Clairo’s sophomore album Sling. Amoebas are unicellular organisms, and the noun comes from the greek amoibe which means “change, alteration, exchange”. As stated by the singer, the theme of the song is in fact changing her priorities:

It’s about prioritizing the wrong things. I’d go out on tour and forget to call my family and my friends, forget to eat, then come home and realize my hair’s falling out because I’m not taking care of myself.

On August 6, 2021, Rolling Stone posted a video of Clairo and producer Jack Antonoff breaking down the track, explaining some of the lyrics and production.