The lyrics explore an American soldier’s mental anguish following his return home from the second Gulf War, and are based on an article entitled “Casualty of War” in Texas Monthly magazine. “Eyes of the Insane” was written by vocalist Tom Araya during pre-production for the album.

The accompanying music video by the Iranian director Tony Petrossian was recorded in the Los Angeles area in August 2006. The film is presented as a close-up of the soldier’s pupil and iris, which reflect disconcerting images of war-themed horrors, flashbacks of his home, wife and children, and ultimately images of his death.