On track 10 off of Drake’s 2021 release Certified Lover Boy, Drake seems to outline the edges of a relationship that did not work out the way he wanted it to. Drake feels like no matter how much he loves her, no matter what he buys her, she’s never gonna be the woman that he needs her to be for him. But, after the breakup, he still cannot get her off of his mind and therefore he writes incessantly trying to quiet the memories of her.
To tell someone to “pipe down” is to tell someone to relax. In this song, it refers to trying to quiet the memories of another person.