Teddy Park, who worked with 2NE1 many times before on their previous extended play 2NE1 and their single “Try to Follow Me”, wrote and produced the song. It is part of the triple “title tracks,” or lead promotional singles, for the album To Anyone, along with “Clap Your Hands” and “Go Away”.
Before the release of To Anyone, it was announced that the song would be part of the three title tracks. The music video was released on September 12, and the first live stage was later that night on Inkigayo. Promotions for the song would last for a month and half before ceasing for “It Hurts (Slow)”.
The English version of “Can’t Nobody” was released on Recochoku, a popular Japanese ringtones website, on January 19, 2011. It also coincided with the release of the music video for the English version. On February 23, 2010, it was announced that it would be packaged with the Japanese version of “Go Away” as 2NE1’s debut single in Japan.