“Annihilate” serves as the introduction to the Spider-Man: Across The Spider-Verse soundtrack. On it, household rap names Lil Wayne, Offset, and Swae Lee put on the spider-mask, and specifically speak about the heroic aspects of taking on the role of Spider-Man.

Snippets of the song surfaced online as Spider-Man: Across The Spider-Verse began premiering, shortly before its worldwide release.