“Real Muthaphuckkin G’s” is Eazy-E’s response to Dr. Dre and his former protege Snoop Doggy Dogg’s numerous disses on The Chronic—most notably “Fuck wit Dre Day (And Everybody’s Celebratin’)”.

Eazy was flanked by Compton’s Gangsta Dresta and Dresta’s little brother B.G. Knocc Out, both newly signed to the Ruthless Records roster, in this first single from the 1993 EP, It’s On (Dr. Dre) 187um Killa. Suge Knight attempted to break Dre away from his Ruthless contract, but Eazy successfully sued and was awarded percentages of Dre’s albums and production work for Death Row, which he revealed to the public on this EP. He was also hip to just how Knight got down, years before Death Row fell apart.

The track samples Eazy’s own “Eazy-Duz-It” and “It’s Funky Enough” by D.O.C.—both were produced by Dre during his tenure at Ruthless.

It’s his most successful single to date peaking at no. 42 in the billboard hot 100