“Hands Up” is the second single from Lloyd Banks' second studio album, Rotten Apple. The chorus is sung by fellow G-Unit member 50 Cent and the video features the former as well as another, G-Unit member Tony Yayo.

The song is produced by Eminem and was released as a digital download on July 25, 2006. “Hands Up” debuted at #84 on the Billboard Hot 100.

It is featured on the soundtrack of Saints Row 2, a video game released in 2008 which sold 3.5 million copies. Big rappers and big songs for big games.