On the titular track to Shakur’s 1995 third studio album, Me Against the World, ‘Pac discusses themes of injustice and unfairness on his lonesome battle against the world. The track features Yaki Kadafi and E.D.I. Mean—members of Shakur’s Outlawz collective. The track is produced by Soulshock & Karlin, who samples Minnie Riperton’s “Inside my Love,” and Isaac Hayes' “Walk On By.”

When discussing the album, 2Pac explained that many of the songs were reflective of his own fears:

Me Against the World was deep, reflective. It was like a blues record. It was down-home. It was all my fears, all the things I just couldn’t sleep about. Everybody thought that I was living so well and doing so good that I wanted to explain it. And it took a whole album to get it all out. It’s explaining my lifestyle, who I am, my upbringing and everything. It talks about the streets but talks about it in a different light.